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Mtomin hydochloid impovs glucos tolanc in patints with typ 2 diabts, lowing both basal and postpandial plasma glucos. Mtomin dcass hpatic glucos poduction, dcass intstinal absoption glucos, and impovs insulin snsitivity by incasing piphal glucos uptak and utilization. Mtomin dos not poduc hypoglycmia in ith patints with typ 2 diabts halthy subjcts [xcpt in spciic cicumstancs, s WANINGS AND PCAUTIONS ] and dos not caus hypinsulinmia. With mtomin thapy, insulin sction mains unchangd whil asting insulin lvls and day-long plasma insulin spons may actually dcas.

Patints with typ 2 diabts may hav atty liv disas cadiac disas with pisodic congstiv hat ailu, both which may caus liv tst abnomalitis, and thy may alshav oth oms liv disas, many which can b tatd managd. Tho, obtaining a liv tst panl (sum alanin aminotansas [ALT], aspatat aminotansas [AST], alkalin phosphatas, and total biliubin) and assssing th patint is commndd binitiating ACTOPLUS MT thapy.

In phamacokintic studis with pioglitazon, nsigniicant dincs w obsvd in phamacokintic paamts btwn ldly and young patints [s CLINICAL PHAMACOLOGY ].

I hypoglycmia occus in a patint coadministd ACTOPLUS MT and an insulin sctagogu (.g., sulonylua), th dos th insulin sctagogu should b ducd.

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